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Accession IconSRP041955

Homo sapiens Transcriptome or Gene expression

Organism Icon Homo sapiens
Sample Icon 40 Downloadable Samples
Technology Badge IconIllumina HiSeq 2000

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Description
The use of low quality RNA samples in whole-genome gene expression profiling remains controversial. It is unclear if transcript degradation in low quality RNA samples occurs uniformly, in which case the effects of degradation can be normalized, or whether different transcripts are degraded at different rates, potentially biasing measurements of expression levels. This concern has rendered the use of low quality RNA samples in whole-genome expression profiling problematic. Yet, low quality samples are at times the sole means of addressing specific questions – e.g., samples collected in the course of fieldwork.
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