Developmental Timecourses total-RNA sequencing [Ribosome repleted total RNA]

We report the presence of extensive, transcriptionally controlled oscillations in the C. elegans, developmental transcriptome. Furthermore, using ribosome profiling, we show that these oscillating transcripts are actively translated. Overall design: Examination of two timecourses that were collected over C. elegans development and analyzed by RNA-seq of "RiboMinus" libraries

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Hendriks GJ, Gaidatzis D, Aeschimann F, Großhans H