Gene expression of three hepatocellular carcinoma cell lines with different organ-tropism.

In this study we investigated the gene expression profiling in three HCC cell lines with different organ-tropism.The parent cell line has low metastasis ability in nude mice model. Subclone 1 has higher metastasis ability specific to lung, and subclone 2 has dual metastasis ability to lung and celiac lymph node. We aimed to explore differentially expressed genes involved in process of HCC metastasis and organ-specific metastasis, and identify their biological functions. Overall design: Examination of different gene expression among the 3 cell types.

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Wan J, Wen D, Dong L, Tang J, Liu D, Liu Y, Tao Z, Gao D, Sun H, Cao Y, Fan J, Wu W