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Accession IconGSE99644

Transcriptome Profiling in KY1005-treated NHP HCT-recipients

Organism Icon Macaca mulatta
Sample Icon 100 Downloadable Samples
Technology Badge Icon Affymetrix Rhesus Macaque Genome Array (rhesus)

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Description
Graft versus host disease (GVHD) is the most common complication of hematopoietic stem cell transplant (HCT). However, our understanding of the molecular pathways that cause this disease remains incomplete, leading to inadequate treatment strategies. To address this, we measured the gene expression profile of non-human primate (NHP) T cells during acute GVHD. In this study we specifically interrogated the transcriptional signatures of animals treated with KY1005 monotherapy and KY1005/Sirolimus combination therapy
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102

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