Gene expression in the embryonic endolymphatic sac of E13.5, E14.5, E16.5 and E17.5 Slc26a4/+ and Slc26a4/ mice

Gene expression was analyzed in endolymphatic sacs of two groups of mice: Slc26a4/ and Slc26a4/+ mice. Slc26a4/ mice fail to develop hearing and are a model for Enlarged Vestibular Aqueduct and Pendred Syndrome, two forms of human deafness that are associated with mutations of SLC26A4. Slc26a4/+ mice develop normal hearing and served a controls. Gene expression was performed at embryonic day (E) 13.5, E14.5, E16.5 and E17.5, which are pathobiologically relevant time points that mark growth and enlargement of the entire inner ear including the cochlea and the vestibular aqueduct.

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