K562 Gene Expression Control vs 1R-Chl treatments

To determine whether the polyamide-Chl conjugate 1R-Chl would cause similar changes in global gene expression in K562 cells, affymetrix gene chip analysis was performed using 1R-Chl. Through class comparison analysis, 1R-Chl affected the levels of transcription and genes of interest were determined.

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Chou CJ, Farkas ME, Tsai SM, Alvarez D, Dervan PB, Gottesfeld JM