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Accession IconGSE87439

Schisandra chinensis extract and TGF-1 effect on gene expression profile in A7r5 rat aortic smooth muscle cell

Organism Icon Rattus norvegicus
Sample Icon 18 Downloadable Samples
Technology Badge Icon Affymetrix Rat Genome 230 2.0 Array (rat2302)

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Description
Schisandra chinensis extract B (SchB) and schisandrol B (SolB) most potently inhibited TGF-1-induced activation and nuclear translocation of NF-B. These effects of SchB and SolB were independent of the Smad-associated canonical pathway. The inhibition of NF-B by SchB and SolB attenuated TGF-1-induced cell migration. Our study demonstrates that SCE and its ingredients SchB and SolB suppressed TGF-1-NF-B signaling axis.
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