Effect of Hypercapnia on Murine Ventilator-Induced Lung Injury

Addition of CO2 to the inspired gas can ameliorate lung injury during high tidal volume mechanical ventilation in animal models. Although some effects of hypercapnia on physiology and cell signaling have been characterized, we hypothesized that assessment of genome-wide gene expression patterns would reveal novel pathways of protection.

35

Otulakowski G, Engelberts D, Arima H, Hirate H, Bayir H, Post M, Kavanagh BP