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Accession IconGSE8510

RAR-PLZF overcomes PLZF-mediated repression of CRABPI contributing to retinoid resistance in t(11;17) APL

Organism Icon Homo sapiens
Sample Icon 4 Downloadable Samples
Technology Badge Icon Affymetrix Human Genome U133A Array (hgu133a)

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This study supports an active role for PLZF and RAR-PLZF in leukemogenesis, identifies upregulation of CRABPI as a novel mechanism contributing to retinoid resistance and reveals the ability of the reciprocal fusion gene products to mediate distinct
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