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Accession IconGSE84842

Expression data from the chronic myeloid leukemia cell line K562 with or without AF1q/MLLT11 overexpressing

Organism Icon Homo sapiens
Sample Icon 6 Downloadable Samples
Technology Badge Icon Affymetrix Human Gene 1.0 ST Array (hugene10st)

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Description
AF1q/MLLT11 expression was significantly upregulated in CML patients and elevated AF1q expression was associated with disease progression. Enforced AF1q expression promoted cell survival, protected CML cells from IM treatment and increased engraftment of CML cells in vivo.
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