github link
Accession IconGSE83578

Sex-specific Variation in Signaling Pathways and Gene Expression Patterns in Human Leukocytes in Response to Endotoxin and Exercise

Organism Icon Homo sapiens
Sample Icon 64 Downloadable Samples
Technology Badge Icon Affymetrix Human Genome U219 Array (hgu219)

Submitter Supplied Information

Description
While exercise effects on the immune system received increasing attention in recent years, it remains unclear to what extent gender and fluctuations in sex hormones during menstrual cycle influence immunological responses to exercise. Using a previously published microarray data set, we investigated mRNA changes induced through exhaustive exercise (half-marathon; pre-exercise and post-exercise [30 min, 3h, 24h], whole blood culture LPS (1h)) with a specific focus on sex differences (women in luteal phase vs men). Inflammation related pathways, TLRs, cytosolic DNA sensing and RIG-I like receptors were differentially activated between sexes in LPS-stimulated cultures. Genes differentially regulated between sexes included TNIP-1, TNIP-3, IL-6, HIVEP1, CXCL3, CCR3, IL-8 and CD69, revealing a bias towards less anti-inflammatory gene regulation in women compared to men. In addition, several genes relevant to brain function (OLIG2, TMEM106B, DDIT4, and KMO) showed differential activation between sexes. Some of these genes (e.g., KMO in women, DDIT4 in both sexes) potentially constitute neuroprotective mechanisms. These data reveal that the exercise-induced change in gene expression might be gender and menstrual cycle phase dependent.
PubMed ID
No associated PubMed ID
Publication Title
No associated publication
Total Samples
64
Submitter’s Institution
Authors
No associated authors

Samples

Show of 0 Total Samples
Filter
Add/Remove
Accession Code
Title
Sex
Treatment
Subject
Processing Information
Additional Metadata
No rows found
Loading...