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Accession IconGSE81012

Expression data from mouse hair follicle stem cells at postnatal day 49 in K14-sPLA2-IIA and wild type mice

Organism Icon Mus musculus
Sample Icon 6 Downloadable Samples
Technology Badge Icon Affymetrix Mouse Gene 2.0 ST Array (mogene20st)

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sPLA2-IIA is involved in lipid catabolism and is deregulated in various human cancers. Our data showed that over expression of sPLA2-IIA in skin disrupts various epidermal lineages, loss of ortho-parakeratotic organization, stem cell depletion/quiescence and increased differentiation potentially associated with global differences in epigenetic status. Our study has provided significant contribution to over existing knowledge of sPLA2-IIA by showing the unexplored role of sPLA2-IIA in hair follicle stem cells and skin homeostasis mediated through JNK/c-Jun signaling mechanism.
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