Genome-wide expression profiling of USP9X/Y knockdown in the DU145 cell culture model

Public transcriptomics studies have shown that several genes display pronounced gender differences in their expression in the human brain, and these differences may influence the clinical manifestations and risk for neuronal disorders. While disease relevant implications have already been proposed for gender differences in hormone levels, life style and genetic diversity, a systems level analysis of brain gene expression disparities between the genders in the context of brain disorders like Alzheimers disease (AD) has not yet been conducted.

15

Köglsberger S, Cordero-Maldonado ML, Antony P, Forster JI, Garcia P, Buttini M, Crawford A, Glaab E