Gene expression studies in IEC-6 cells induced by non-steroidal anti-inflammatory agents

Non-steroidal anti-inflammatory drugs (NSAIDs) are used extensively as therapeutic agents, despite their well-documented gastrointestinal (GI) toxicity. Presently, the mechanisms responsible for NSAID-associated GI damage are incompletely understood. In this study, we used Microarray analysis to generate a novel hypothesis about cellular mechanisms that underlie the GI toxicity of NSAIDs. Monolayers of intestinal epithelial

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Raveendran NN, Silver K, Freeman LC, Narvaez D, Weng K, Ganta S, Lillich JD