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Accession IconGSE75535

Gene expresssion profiles of cancer of the appendix

Organism Icon Homo sapiens
Sample Icon 63 Downloadable Samples
Technology Badge Icon Affymetrix Human Genome U219 Array (hgu219), Affymetrix Human Genome U133A 2.0 Array (hgu133a2)

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Description
Appendiceal cancer patients treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) often demonstrate an unpredictable variability in survival outcomes. Biomarkers predictive of CRS/HIPEC efficacy could better guide treatment decisions. In this study we hypothesized that variation in the transcriptional programming of appendiceal tumors might distinguish molecular subtypes with differential outcomes after CRS/HIPEC. The goal of this study was to investigate the potential of a prognostic gene signature to discriminate patients with favorable and unfavorable outcomes in a discovery set of patient (the original tumor series (n=24)), and confirm its prognostic value in a second validation series (the validation cohort (n=39)).
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63
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