Intragraft gene expression profile associated with the induction of tolerance

Xenotransplantation holds the promise of providing an unlimited supply of donor organs for terminal patients with organ failure. The gal carbohydrate results in rejection of wild type pig grafts, however, chimerism established by expression of the GalT gene prior to transplantation in GalT knockout mice results in tolerance to Gal+ heart grafts.

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Doki T, Mello M, Mock D, Evans JM, Kearns-Jonker M