Expression data from UMUC3 cells transduced with non-targeted shRNA and shRNA specific to AGL

Loss of Amylo-alpha-1-6-glucosidase-4-alpha-glucanotransferase (AGL) drives bladder cancer growth. Low AGL expression predicts poor patient outcome. Currently no specific therapeutically tractable targets/pathways exist that could be used to treat patients with low AGL expressing bladder tumors.

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Guin S, Ru Y, Agarwal N, Lew CR, Owens C, Comi GP, Theodorescu D