A549 Gene Expression Following Treatment with a No-Observed-Effect Level of Cisplatin

GSE73302

Homo sapiens

12 Downloadable Samples

Affymetrix Human Human Exon 1.0 ST Array (huex10st)

Submitter Supplied Information

Description

We compared the gene expression of A549 cells following 24 and 48 hours of treatment with a no-observed-effect level dose of cisplatin. The objective of the study is to identify genes that are differentially expressed in response to sub-lethal doses of cisplatin. This study helps identify not only treatment responses but also changes in gene expression that may confer cytoprotective mechanisms that allow these cells to survive treatment and to develop treatment resistance.

PubMed ID

26938915

Publication Title

Combined Use of Gene Expression Modeling and siRNA Screening Identifies Genes and Pathways Which Enhance the Activity of Cisplatin When Added at No Effect Levels to Non-Small Cell Lung Cancer Cells In Vitro.

Total Samples

Submitter’s Institution

BC Cancer Research Centre

Authors

Leung AW, Hung SS, Backstrom I, Ricaurte D, Kwok B, Poon S, McKinney S, Segovia R, Rawji J, Qadir MA, Aparicio S, Stirling PC, Steidl C, Bally MB

Source Repository

Gene Expression Omnibus (GEO)

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