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Accession IconGSE7159

Transcriptional response to MnSOD over-expression in Drosophila melanogaster

Organism Icon Drosophila melanogaster
Sample Icon 20 Downloadable Samples
Technology Badge Icon Affymetrix Drosophila Genome Array (drosgenome1)

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Description
Profiled the transcriptional response to over-expression Manganese-SOD (MnSOD) in adult Drosophila. A doxycycline-regulated system was employed to induce MnSOD over-expression, resulting in mean and maximal lifespan increases of ~ 20%. Examination of the genome-wide response to this lifespan intervention provided key insights into the molecular basis of aging.
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