Transcriptome profiling of control and FOSL1 knockdown Rcho-1 trophoblast stem (TS) cells

In hemochorial placentation, trophoblast stem cells differentiate into multiple lineages to aquire specific functions, such as invasive and endocrine phenotype. FOSL1 has been identified as a key regulator for trophoblast differentiation. We used microarray to detail mechanisms underlying FOSL1 signaling pathway in trophoblast differentiation.

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Kubota K, Kent LN, Rumi MA, Roby KF, Soares MJ