Adaptation of HepG2 Cells to a Steady-State Reduction in the Content of Protein Phosphatase 6 (PP6) Catalytic Subunit

To assess the potential of PP6 as a therapeutic target in liver disorders, we attenuated expression of the PP6 catalytic subunit in HepG2 cells using lentiviral-transduced shRNA. Two PP6 knock-down (PP6KD) cell lines 18.5 and 19.5, (90% reduction of PP6-C protein content) were studied in depth.

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Boylan JM, Salomon AR, Tantravahi U, Gruppuso PA