Regulation of Rat Hepatic Translation by mTOR

GSE67022

Rattus norvegicus

40 Downloadable Samples

Affymetrix Rat Gene 1.0 ST Array (ragene10st)

Submitter Supplied Information

Description

Our strategy was to manipulate mTOR signaling in vivo, then characterize the transcriptome and translating mRNA in liver tissue. In adult rats, we used the non-proliferative growth model of refeeding after a period of fasting, and the proliferative model of liver regeneration following partial hepatectomy. We also studied livers from pre-term fetal rats (embryonic day 19-20) in which fetal hepatocytes are asynchronously proliferating. All three models employed rapamycin to inhibit mTOR signaling.

PubMed ID

25924882

Publication Title

Profiling of the fetal and adult rat liver transcriptome and translatome reveals discordant regulation by the mechanistic target of rapamycin (mTOR).

Total Samples

Submitter’s Institution

Rhode Island Hospital

Authors

Boylan JM, Sanders JA, Neretti N, Gruppuso PA

Source Repository

Gene Expression Omnibus (GEO)

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