Knockdown of TSPAN8 gene expression in the SH-SY5Y neuroblastoma cell line

Bipolar disorder (BD) has an estimated heritability of about 80%. Different pathways and candidate genes may contribute to the pathogenesis of BD, but definite mechanisms are yet unresolved. In a previous study, we identified the single nucleotide polymorphism (SNP) rs4500567, located in the upstream region of Tetraspanin 8 (TSPAN8), to be associated with bipolar disorder (BD).

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Schartner C, Scholz CJ, Weber H, Post A, Freudenberg F, Grünewald L, Reif A