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Accession IconGSE65055

Expression data from euploid and trisomic 13, 18 and 21 human fetal cells

Organism Icon Homo sapiens
Sample Icon 12 Downloadable Samples
Technology Badge Icon Affymetrix Human Gene 2.0 ST Array (hugene20st)

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Description
The organization and dynamics of chromatin within the in vivo interphase nucleus and the latter's relationship with transcriptional regulation are still not fully understood. To better understand these relationships, we studied a natural example of chromosomal disorganization: aneuploidy due to trisomies 13, 18 and 21. We hypothesized that the presence of an extra copy of one chromosome alters the CT distribution in the nucleus, which in turn perturbs transcriptional activity.
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