Altered epithelial gene expression in peripheral airways of severe asthma

Management of severe asthma remains a challenge despite treatment with glucocorticosteroid therapy. The majority of studies investigating disease mechanisms in treatment-resistant severe asthma have previously focused on the large central airways, with very few utilizing transcriptomic approaches. The small peripheral airways, which comprise the majority of the airway surface area, remain an unexplored area in severe asthma and were targeted for global epithelial gene expression profiling in this study.

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Singhania A, Rupani H, Jayasekera N, Lumb S, Hales P, Gozzard N, Davies DE, Woelk CH, Howarth PH