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Accession IconGSE63051

Genome-wide analysis of gene expression in DJ-1 deficient muscle cells

Organism Icon Mus musculus
Sample Icon 6 Downloadable Samples
Technology Badge IconIllumina MouseWG-6 v2.0 expression beadchip

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Description
Excessive reactive oxygen species (ROS) underlie the pathogenesis of multiple disorders. Nevertheless, physiological levels of ROS are required for intracellular signalling and maintenance of metabolic homeostasis. DJ-1, a Parkinsons disease-associated protein, is involved in the regulation of oxidative stress. Our aim in this study was to determine the effect of DJ-1 disruption on gene expression in muscle cells. To this end, we transfected a murine myoblast cell line, C2C12 cells with siRNA targeting DJ-1.
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