Expression data from primary rat aortic smooth muscle cells

Electrochemical gradients of monovalent cations across the plasma membrane (high intracellular potassium, [K+]i vs low intracellular sodium, [Na+]i) are created by the Na+,K+-pump and determine a large variety of physiologically important processes. We hypothesized that transcriptomics changes triggered by hypoxia are at least partially caused by Na+i/K+i-mediated excitation-transcription coupling .

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Koltsova SV, Shilov B, Birulina JG, Akimova OA, Haloui M, Kapilevich LV, Gusakova SV, Tremblay J, Hamet P, Orlov SN