Effect of NDRG3 expression on cell response to hypoxia

Analysis of Huh-7 hepatocarcinoma cell line depleted of NDRG3 or HIF-1 under hypoxic condition. HIF-1 and NDRG3 have distinct functions in hypoxia responses. Results provide insight into molecular basis of HIF-independent signaling in the development and progression of hypoxic tumors

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Lee DC, Sohn HA, Park ZY, Oh S, Kang YK, Lee KM, Kang M, Jang YJ, Yang SJ, Hong YK, Noh H, Kim JA, Kim DJ, Bae KH, Kim DM, Chung SJ, Yoo HS, Yu DY, Park KC, Yeom YI