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Accession IconGSE56406

Global gene expression analyses of paused iPSCs

Organism Icon Mus musculus
Sample Icon 24 Downloadable Samples
Technology Badge IconIllumina MouseRef-8 v2.0 expression beadchip

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Description
Low Klf4 expression reproducibly gives rise to a homogeneous population of partially reprogrammed iPSCs. Upregulation of Klf4 allows these cells to resume reprogramming, indicating that they are paused iPSCs that remain on the path towards pluripotency. Paused iPSCs with different Klf4 expression levels remain at distinct intermediate stages of reprogramming.
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