TNF-alpha and IL-17 synergize to inhibit IL-13 bioactivity via IL-13Ra2 induction in human lung fibroblasts

GSE56338

Homo sapiens

23 Downloadable Samples

Illumina HumanHT-12 V4.0 expression beadchip

Submitter Supplied Information

Description

IL-17 and TNF-alpha synergistically induce surface expression of IL-13Ra2 on primary lung fibroblasts, rendering them unresponsive to IL-13. Neutralizing antibodies to IL-13Ra2 restored IL-13-mediated signaling and transcriptome studies confirmed IL-13Ra2 is an IL-13 decoy receptor.

PubMed ID

24954262

Publication Title

TNF-α/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction.

Total Samples

Submitter’s Institution

National Institute of Allergy and Infectious Diseases

Authors

Badalyan V, Thompson R, Addo K, Borthwick LA, Fisher AJ, Ort T, Myers TG, Wynn TA, Ramalingam TR

Source Repository

Gene Expression Omnibus (GEO)

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