Perinatal malnutrition in male mice influences gene expression in the next generation offspring: Potential role of epigenetics.

Perinatal nutritional imbalances may have long-lasting consequences on health and disease, increasing risk of obesity, insulin resistance, type 2 diabetes or cardiovascular disease. This idea has been conceptualized in the Developmental Origins of Health and Disease Hypothesis (DOHaD). In addition, there is evidence that such early-programmed phenotypes can be transmitted to the following generation(s). It is proposed that, environmentally induced, transmission of disease risk is mediated by epigenetic mechanisms.

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Martínez D, Pentinat T, Ribó S, Daviaud C, Bloks VW, Cebrià J, Villalmanzo N, Kalko SG, Ramón-Krauel M, Díaz R, Plösch T, Tost J, Jiménez-Chillarón JC