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Accession IconGSE54356

Gene regulation in denervated hairy skin of the adult rat

Organism Icon Rattus norvegicus
Sample Icon 16 Downloadable Samples
Technology Badge Icon Affymetrix Rat Genome 230 2.0 Array (rat2302)

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Description
This study aimed to quantify the regulation of transcripts in the hairy skin of the back of adult rats in the condition of loss of sensory and autonomic (sympathetic) innervation (i.e., denervated). Denervated skin has reduced wound healing capacity, reduced proliferation of epidermal progenitor cells, and also expresses factors that regulate ingrowth of sensory and sympathetic axons from neighboring regions of innervated skin. It was expected that this quantification f transcript regulation would offer insight into the general and specific mechanisms that may contribute to these important biological processes.
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