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Accession IconGSE54085

Gene expression analysis of rat glomerular parietal epithelial cells

Organism Icon Rattus norvegicus
Sample Icon 6 Downloadable Samples
Technology Badge Icon Affymetrix Rat Gene 1.0 ST Array (ragene10st)

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Description
Very little is known about the function of glomerular parietal epithelial cells (PECs). In this study, we performed genome-wide expression analysis on PEC-enriched capsulated vs. PEC-deprived decapsulated rat glomeruli to determine the transcriptional state of PECs under normal conditions. We identified hundreds of differentially expressed genes that mapped to distinct biologic modules including development, tight junction, ion transport, and metabolic processes. Since developmental programs were highly enriched in PECs, we characterized several of their candidate members at the protein level. Collectively, our findings confirm that PECs are multifaceted cells and help define their diverse functional repertoire.
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