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Accession IconGSE53808

White Matter transcriptome in chronic alcoholism

Organism Icon Homo sapiens
Sample Icon 32 Downloadable Samples
Technology Badge Icon Affymetrix Human Genome U219 Array (hgu219)

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Description
Chronic alcohol consumption can lead to alchohol-related brain damage (ARBD). Despite the well known acute effects of alcohol the mechanism responsible for chronic brain damage is largely unknown. Pathologically the major change is the loss of white matter while neuronal loss is mild and restricted to a few areas such as the prefrontal cortex. In order to improve our understanding of ARBD pathogenesis we used microarrays to explore the white matter transcriptome of alcoholics and controls.
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