TTP mRNA targets identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts

Tristetraprolin (TTP) is a tandem CCCH zinc finger protein that was identified through its rapid induction by mitogens in fibroblasts. Studies of TTP-deficient mice, and cells derived from them, showed that TTP could bind to certain AU-rich elements in mRNAs, leading to increases in the rates of mRNA deadenylation and destruction. Known physiological target

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Lai WS, Parker JS, Grissom SF, Stumpo DJ, Blackshear PJ