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Accession IconGSE53230

Gene expression analysis in liver collected from mice administered non-toxic, toxic, or severely toxic LNA sequences

Organism Icon Mus musculus
Sample Icon 56 Downloadable Samples
Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

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Description
Development of LNA gapmers, antisense oligonucleotides used for efficient inhibition of target RNA expression, is limited by non-target mediated hepatotoxicity issues. In the present study, we investigated hepatic transcription profiles of mice receiving non-toxic and toxic LNA gapmers after a single and repeat administration.
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56
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