Expression data from human glioma cancer stem cell (CSC) specimens following knockdown of GREM1

GSE52846

Homo sapiens

6 Downloadable Samples

Affymetrix Human Gene 2.1 ST Array (hugene21st)

Submitter Supplied Information

Description

CSCs differentially secrete the BMP antagonist Gremlin1 compared to non-stem glioma populations. Knockdown of Gremlin1 decreases CSC proliferation and tumorigenicity, establishing Gremlin1 as an essential effector for CSC maintenance.

PubMed ID

24788093

Publication Title

Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy.

Total Samples

Submitter’s Institution

Cleveland Clinic Lerner Research Institute

Authors

Yan K, Wu Q, Yan DH, Lee CH, Rahim N, Tritschler I, DeVecchio J, Kalady MF, Hjelmeland AB, Rich JN

Source Repository

Gene Expression Omnibus (GEO)

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