Profiling of CD4+ T cells responding to transient or persistent antigen presented by dendritic cells in vivo

These experiments were done to compare the gene expression profiles in CD4+ T cells responding to antigen presented by dendritic cells transiently or persistently. Some treatments include the activation of the dendritic cells by CD40 engagement.

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Obst R, van Santen HM, Melamed R, Kamphorst AO, Benoist C, Mathis D