Expression data of human CD4 T cells with chronic or acute simian immunodeficiency virus (SIV) infection

We compared gene expression profiles of a human CD4+ T-cell line 24 h after infection with a cell line of the same origin permanently releasing SIVmac251/32H. A new knowledge-based-network approach (Inter-Chain-Finder) was used to identify subnetworks leading to resistance to SIV-induced cell death. Notably, the method can identify not only differentially-expressed key hub genes but also non-differentially expressed, critical, hidden regulators.

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He FQ, Sauermann U, Beer C, Winkelmann S, Yu Z, Sopper S, Zeng AP, Wirth M