Expression data from WT and Eed KO neonatal mouse LT-HSC

Recent studies point to a pivotal role of polycomb repressive complex 2 (PRC2) in stem cell function and cancer. Loss of function approaches targeting individual PRC2 subunits have however generated findings that are difficult to reconcile.

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Xie H, Xu J, Hsu JH, Nguyen M, Fujiwara Y, Peng C, Orkin SH