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Accession IconGSE49663

Gene expression in the blood of Live Attenuated Rev-Independent NefSIV infected Rhesus macaques during acute infection

Organism Icon Macaca mulatta
Sample Icon 6 Downloadable Samples
Technology Badge Icon Affymetrix Rhesus Macaque Genome Array (rhesus)

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Description
Rhesus macaques (RMs) inoculated with live-attenuated Rev-Independent Nef simian immunodeficiency virus (Rev-Ind NefSIV) as adults or neonates controlled viremia to undetectable levels and showed no signs of immunodeficiency over 6-8 years of follow-up. We tested the capacity of this live-attenuated virus to protect RMs against pathogenic, heterologous SIVsmE660 challenges
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