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Accession IconGSE49019

HIV-1 gp120 impairs B cell proliferation by inducing TGF-1 production and FcRL4 expression via an 47-dependent mechanism

Organism Icon Homo sapiens
Sample Icon 41 Downloadable Samples
Technology Badge Icon Affymetrix Human Gene 1.0 ST Array (hugene10st)

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Description
The anti-HIV humoral immune response following acute infection is delayed and ineffective. HIV envelope protein gp120 binds to and signals through 47 on T cells. We show that gp120 also binds and signals through 47 on B cells, resulting in an abortive proliferative response. In primary B cells, gp120 signaling through 47 resulted in increased expression of TGF-1 and the B cell inhibitory receptor FcRL4. Co-culture of B cells with HIV-infected autologous CD4+ T cells also resulted in increased B cell FcRL4 expression. These findings indicate that, in addition to inducing chronic immune activation, viral proteins can contribute directly to HIV-associated B cell dysfunction, thus providing a mechanism whereby the virus subverts the early HIV-specific humoral immune response.
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