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Accession IconGSE48255

Expression data from GGF2-treated post-MI swine

Organism Icon Sus scrofa
Sample Icon 8 Downloadable Samples
Technology Badge Icon Affymetrix Porcine Genome Array (porcine)

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Description
Neuregulin-1 (NRG-1) is a paracrine factor critical for cardiac development. We have been examining whether the recombinant NRG-1 isoform known as glial growth factor 2 (GGF2) has therapeutic potential for heart failure. In both small and large animals after experimental myocardial infarction (MI) we have found that GGF2 treatment improves myocardial function and limits progressive myocardial remodeling. To understand potential mechanisms for this effect, we compared gene expression in swine by microarray analysis.
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