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Accession IconGSE47734

Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice [BeadArray]

Organism Icon Mus musculus
Sample Icon 1 Downloadable Sample
Technology Badge IconIllumina MouseRef-8 v2.0 expression beadchip

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The preferential localization of some neoplasms, such as serrated polyps, in specific areas of the intestine suggests that non-genetic factors may be important for their development. To test this hypothesis, we took advantage of transgenic mice that expressed HB-EGF throughout the intestine, but develop serrated polyps only in the cecum.
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