Decline of Nucleotide Excision Repair Capacity in Aged Caenorhabditis elegans

We used gene expression profiling to address several specific questions that arose in a study of repair of ultraviolet C radiation in C elegans, as well as to generate hypotheses regarding the possible mechanism(s) of decreased DNA repair observed in old adults in that study. This analysis was performed in order to analyze gene expression in the strain (JK1107) and experimental conditions that we used for our DNA repair studies.

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Meyer JN, Boyd WA, Azzam GA, Haugen AC, Freedman JH, Van Houten B