Expression Data from murine control and IL6ralpha-deficient macrophages stimulated with Interleukin-6

GSE47426

Mus musculus

8 Downloadable Samples

Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Submitter Supplied Information

Description

IL-6 induces IL4ralpha expression in macrophages. This mechanism is necessary to promote macrophage polarization towards an M2-phenotype and is crucial to limit the inflammatory response both upon obesity and LPS-endotoxemia.

PubMed ID

24681566

Publication Title

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin.

Total Samples

Submitter’s Institution

Weill Medical College, Cornell University

Authors

Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, Theurich S, Hausen AC, Schmitz J, Brönneke HS, Estevez E, Allen TL, Mesaros A, Partridge L, Febbraio MA, Chawla A, Wunderlich FT, Brüning JC

Source Repository

Gene Expression Omnibus (GEO)

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