Age-mediated transcriptomic changes in adult mouse brain ventral tegmental area

Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson's disease. However, ventral tegmental area (VTA), a region adjacent to SNpc, is less affected in PD. Until now, molecular mechanisms behind VTA aging have not been fully investigated using high throughput techniques.

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Gao L, Hidalgo-Figueroa M, Escudero LM, Díaz-Martín J, López-Barneo J, Pascual A