Comparative analysis of gene expression in Fra-1+/+ and Fra-1-/- mice lung

We hypothesized that gene expression in lungs of Fra-1+/+ and Fra-1-/- mice are divergent thus contributing fibrosis. More specifically, Fra-1-/- mice are increased susceptible to fibrosis. In order to test these hypotheses at the gene expression level, we utilized microarray analysis to examine transcriptional differences between Fra-1+/+ and Fra-1-/- mice at early time point.

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Rajasekaran S, Reddy NM, Zhang W, Reddy SP