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Accession IconGSE42458

Budding yeast Wapl controls sister chromatid cohesion maintenance and the chromosome condensation status [expression]

Organism Icon Saccharomyces cerevisiae
Sample Icon 4 Downloadable Samples
Technology Badge Icon Affymetrix Yeast Genome 2.0 Array (yeast2)

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Description
Cohesin acetylation by Eco1 during DNA replication establishes sister chromatid cohesion. We show that acetylation makes cohesin resistant to Wapl activity from S-phase until mitosis. Wapl turns out to be a key regulator of cohesin dynamics on chromosomes by controling cohesin maintenance following its establishment in S-phase and its role in chromosome condensation.
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