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Accession IconGSE4201

Zebrafish microRNA miR-430 promotes deadenylation and clearance of maternal mRNAs

Organism Icon Danio rerio
Sample Icon 15 Downloadable Samples
Technology Badge Icon Affymetrix Zebrafish Genome Array (zebrafish)

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Description
MicroRNAs comprise 1-3% of all vertebrate genes, but their in vivo functions and mechanisms of action remain largely unknown. Zebrafish miR-430 is expressed at the onset of zygotic transcription and regulates morphogenesis during early development. Using a microarray approach and in vivo target validation, we find that miR-430 directly regulates several hundred target mRNAs. Targets are highly enriched for maternal mRNAs that accumulate in the absence of miR-430. We also show that miR-430 accelerates the deadenylation of target mRNAs. These results suggest that miR-430 facilitates the deadenylation and clearance of maternal mRNAs during early embryogenesis.
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